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Overdose Data to Action: Limiting Overdose through Collaborative Actions in Localities (OD2A: LOCAL)


Additional Links

Notice of Funding Opportunity (


Letter of Intent (Optional): Apr 6, 2023
Application Deadline: May 8, 2023


Centers for Disease Control and Prevention (CDC)


Awards funding to strengthen city or county local health departments' or their bona fide agents, special district health departments', and territorial governments' ability to use data to determine and implement actions to reduce overdose morbidity and mortality in communities, focusing on opioids and/or stimulants. Seeks to reduce health disparities and increase access to care and services for populations most at risk of overdose, including rural communities and tribal populations.

Component A is required and comprised of core prevention and surveillance strategies.

The Prevention Component is comprised of 3 required strategies focused on:

  • Linkage to and Retention in Care to connect people to services, care activities, supports for retentions in care, recovery, and re-engagement in care.
  • Harm Reduction to implement strategies to increase treatment entry, reduce the frequency of drug use, and improve the overall health and wellness of persons who use drugs (PWUDs) with a focus on reducing overdoses.
  • Clinician and Health Systems Best Practices to improve the clinical management of pain and substance use disorder (SUD), and build healthcare infrastructure to improve care coordination.

Optional prevention strategies include:

  • Stigma Reduction
  • Health IT Enhancements

The Surveillance Component is comprised of 1 required strategy focused on:

  • Overdose Surveillance Infrastructure to improve and enhance the overall capacity of the grantee to conduct overdose-related surveillance.

An optional, competitive application process is available for:

  • Component B - Toxicologic Testing of Drug Product and/or Paraphernalia
  • Component C- Surveillance of Linkage to and Retention in Care

Additional information on the priority strategies and related activities, as well as short-, intermediate-, and long-term outcomes, is available in the program guidance.

Amount of Funding

Average 1-year award amounts:

  • Component A: $2,000,000
  • Component B and C: $250,000 - $325,000
Project period: 5 years
Estimated number of awards: 40
Estimated total program funding: $400,000,000

Who Can Apply

City or county local health departments or their bona fide agents, special district health departments, and territorial governments are eligible to apply.

Geographic Coverage


What This Program Funds

Capacity Building • Operating Costs and Staffing

Application Process

Application instructions, requirements, and other information about the online application process are available in the funding announcement.

Letter of intent (LOI) requested but not required.


For programmatic or technical questions:
Yarkasah Paye

For grants management or budget questions:
Darryl Mitchell

Topics This Program Addresses

Harm Reduction • Medication-Assisted Treatment (MAT) • Naloxone • Opioids • Overdose Prevention • Pain Management and Opioid Prescribing • Prevention • Recovery • Substance Use Disorder • Treatment