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Combating Overdose Through Community-Level Intervention (COCLI)



Application Deadline: Nov 6, 2023


Centers for Disease Control and Prevention (CDC), Office of National Drug Control Policy (ONDCP)


Provides funding to conduct and evaluate research designed to help communities address opioid, stimulant, and/or poly-drug overdose in regions of the U.S. with the highest rates of fatal and non-fatal overdose.

Grants are awarded following a 3-tier system:

  • Tier 1 awards fund planning activities for innovative approaches that engage the community to identify causes and potential solutions to the problem of overdose
  • Tier 2 awards support the development of small innovative projects utilizing a novel program, strategy, or approach that has not been evaluated, or projects that adapt an existing evidence-based strategy for use in new setting or with new populations
  • Tier 3 awards focus on implementation and evaluation of medium-sized projects that have some evidence base but would benefit from full implementation and evaluation

Required grant activities include:

  • Support and promote collaboration between public safety and public health agencies to ensure that overdose reduction efforts are aligned and communities benefit from a comprehensive and coordinated response
  • Leverage evidence-based or promising approaches to implement or enhance new or on-going community-based programs that aim to reduce drug overdose
  • Evaluate interventions to assess their effectiveness in reducing overdose and other harms associated with drug use

Amount of Funding

  • Tier 1: Up to $50,000
  • Tier 2: Up to $150,000
  • Tier 3: $150,001 to $200,000

Project period: 1 year

Who Can Apply

Applications may be submitted by:

  • High Intensity Drug Trafficking Areas (HIDTA) programs
  • Public/State-controlled and private institutions of higher education
  • Nonprofit organizations with or without 501(c)(3) status
  • State governments
  • County, city, township, or special district governments
  • Federally recognized Native American tribal governments
  • Native American tribal governments and tribal organizations other than federally recognized
  • U.S. territories or possessions
  • Independent school districts
  • Public housing authorities and Indian housing authorities
  • Faith-based or community-based organizations

Applicant organizations:

  • Must partner with a regional High Intensity Drug Trafficking Areas (HIDTA) program, and applications must include a letter of support/commitment from the participating HIDTA signed by the sponsoring HIDTA Director
  • Must have expert knowledge and extensive experience in conducting research and analysis
  • Must have expert knowledge and experience developing or enhancing new or ongoing programs that aim to reduce opioid or other drug overdose through strategic, evidence-based approaches

Priority is given to projects focused on the following areas:

  • Activities that research and analyze a range of existing community-based efforts to address overdoses
  • Evidence-based and proven strategies designed to reduce overdose deaths that incorporate approaches that advance equity
  • Research activities that address opioid-involved overdose, overdose involving stimulants, or poly-drug overdose, and other harms associated with substance use
  • Research activities that deal with adverse childhood experiences (ACEs)

Geographic Coverage


What This Program Funds

Buildings and Facilities • Capacity Building • Equipment • New Program • Operating Costs and Staffing

Application Process

Application instructions, requirements, and other information about the application process are available in the program guidance.


For program questions or general assistance:
Jeff Beeson

Rural Awards

Past awards communities received in fiscal year 2023 can be found on the program website.

One rural organization that received funding is the Community Coalition Alliance, Inc. in partnership with the Hamilton County Alcohol and Other Drug Prevention Coalition, Inc. in Florida which will conduct community assessment and planning to develop a comprehensive response to the problem of substance use and overdose through prevention, treatment, and recovery efforts.

Topics This Program Addresses

Adverse Childhood Experiences • Community Planning and Coalition Building • Harm Reduction • Justice System • Opioids • Overdose Prevention