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Minority AIDS Initiative: Substance Use Disorder Treatment for Racial/Ethnic Minority Populations at High Risk for HIV/AIDS (MAI: High Risk Populations)


Additional Links

Notice of Funding Opportunity (


Application Deadline: May 22, 2023


Substance Abuse and Mental Health Services Administration (SAMHSA)


Funds programs to address interrelated issues of substance use disorder (SUD), HIV, and mental health problems among medically underserved racial and ethnic minority populations at risk or with HIV. Focuses engaging individuals in the target populations, providing HIV testing, and connecting individuals with appropriate follow-up care, and evidence-based prevention, treatment, and recovery services.

Required program activities include:

  • Provide SUD/COD treatment and recovery support services to individuals with or at risk for HIV, including screening/assessment, outpatient services, intensive outpatient services, and Food and Drug Administration (FDA)-approved medication for the treatment of SUDs and/or COD
  • Provide on-site preliminary HIV testing and provide confirmatory testing either on-site or through connection to a certified local health department
  • Offer all clients and their partners who use drugs and/or sexual partners HIV rapid preliminary antibody testing at enrollment, including rapid 4th generation HIV diagnostic testing
  • Provide or link clients who test positive for HIV on preliminary testing to confirmatory testing with follow-up by the grantee on the client's HIV status
  • Provide education, case management, referral/linkages to follow-up care and treatment for all clients who have a preliminary positive HIV and confirmatory HIV test results
  • Provide education, case management, referral/linkage to pre-exposure prophylaxis (PrEP) services for individuals who screen negative for HIV but are at increased risk of exposure to HIV
  • Provide education, case management, referral/linkage to post-exposure prophylaxis (PEP) services for individuals who are at increased risk of exposure to HIV through exposure
  • Partner with primary HIV treatment and care providers, including Ryan White providers, to strengthen integration of care through case management
  • Screen and assess individuals with or at risk for HIV for the presence of CODs and use this information to develop individualized treatment approaches
  • Test all clients at risk for viral Hepatitis B and C either on-site or through referral and report all positive test results to the local and state health department, as appropriate and legally required
  • Develop a continuous outreach strategy with input from the target population
  • Implement an ongoing strategy to continually reach and provide substance use disorder treatment services to the target population
  • Hire staff that represent the population of the community being served and translate tools and resources available to recipients of services

Amount of Funding

Award ceiling: $500,000 per year
Project period: Up to 5 years
Estimated number of awards: 42
Estimated total program funding: $20,900,000

At least 5 awards will be made to federally recognized American Indian/Alaska Native (AI/AN) tribes and tribal organizations.

Who Can Apply

Eligible applicants include:

  • States and territories
  • Political subdivisions of states
  • Indian tribes
  • Tribal organizations
  • Health facilities
  • Programs operated by or in accordance with a contract or award with the Indian Health Service (IHS)
  • Other public or private non-profit entities

Additional provision of service requirements include:

  • A provider organization for SUD treatment services appropriate to the grant must be involved in the proposed project. The provider may be the applicant or another organization committed to the project. More than 1 provider organization may be involved.
  • Each mental health/SUD treatment provider organization must have at least 2 years experience providing relevant services to individuals from racial and ethnic medically underserved communities disproportionately affected by HIV/AIDS and HIV-related health disparities.
  • Each mental health/SUD treatment provider organization must comply with all applicable local, city, county, and state licensing, accreditation, and certification requirements, as of the due date of the application.

Grantees that received a Minority AIDS Initiative: Substance Use Disorder Treatment for Racial/Ethnic Minority Populations at High-Risk for HIV/AIDS awards under announcements TI-19-008 in fiscal year (FY) 2019 and TI-22-004 in FY 2022 are not eligible to apply.

Geographic Coverage


What This Program Funds

New Program • Operating Costs and Staffing • Training Providers

Application Process

Application instructions, requirements, and information can be found in the funding announcement.


For programmatic or technical questions:
Kirk E. James, MD

For grants management or budget questions:

For grant review process and application status questions:
Gabriela Porter

Topics This Program Addresses

American Indians, Alaska Natives, and Native Hawaiians • Harm Reduction • Housing and Homelessness • Infectious Diseases • Medication-Assisted Treatment (MAT) • Mental Health • Opioids • Prevention • Recovery • Social Services • Substance Use Disorder • Treatment • Violence, Trauma, and Abuse