Twelve tribally and federally operated residential treatment facilities located across the U.S. to address substance use disorder (SUD) and/or co-occurring mental health disorders (COD) among American Indian and Alaska Native (AI/AN) youth and their families at no cost. Provides a range of education and culture-based prevention initiatives, evidence-based and practice-based models of treatment, family strengthening and recreational activities designed to help AI/AN youth overcome challenges related to mental health and substance use. Promotes holistic, culturally responsive care that integrates clinical services with traditional healing, spiritual values, and cultural identification in a substance-free residential environment to support AI/AN youth in achieving their treatment goals and leading healthy, resilient lives.

Offers evidence-based, voluntary programs that provide families with regular, planned home visits from qualified health, social service, and child development professionals. Supports at-risk pregnant women and parents with children up to kindergarten entry with resources to raise physically, socially, and emotionally healthy children. Provides guidance on parenting and health topics, such as breastfeeding, safe sleep practices, injury prevention, nutrition, and childcare solutions. Seeks to improve maternal and child health, prevent child abuse and neglect, encourage positive parenting, and promote child development and school readiness.

Offers appropriate follow-up support services for individuals identified with sickle cell disease and sickle cell trait. Aims to improve care for sickle cell disease and reduce the number of individuals who do not receive follow-up care. Services are provided through local community-based organizations located in 16 states across the U.S.

Supports five regional coordinating centers that serve 30 states to expand access to quality care for patients with sickle cell disease. Works with sickle cell centers, primary care sites, community-based organizations, parents, and patients to provide coordinated, comprehensive, culturally competent, and family-centered care.

Provides telephone-based lifestyle coaching to veterans with services focused on areas such as alcohol use, food consumption, weight management, stress reduction, and more.