Twelve tribally and federally operated residential treatment facilities located across the U.S. to address substance use disorder (SUD) and/or co-occurring mental health disorders (COD) among American Indian and Alaska Native (AI/AN) youth and their families at no cost. Provides a range of education and culture-based prevention initiatives, evidence-based and practice-based models of treatment, family strengthening and recreational activities designed to help AI/AN youth overcome challenges related to mental health and substance use. Promotes holistic, culturally responsive care that integrates clinical services with traditional healing, spiritual values, and cultural identification in a substance-free residential environment to support AI/AN youth in achieving their treatment goals and leading healthy, resilient lives.