Supports projects to address the crisis of substance and opioid use in Appalachian counties through programs that help people in recovery obtain and maintain employment. Promotes the development of recovery ecosystems that support individuals as they transition from substance use disorder (SUD) treatment programs into recovery and seek to enter or re-enter the workforce. Brings together multiple sectors, including recovery communities, peer support, healthcare, human services, law enforcement, and others, to deliver job training, skill development, and comprehensive support services that enable individuals to find stable employment and sustain their recovery from SUD.

Funds economic revitalization projects in the Appalachian region focused on building businesses, workforce ecosystems, infrastructure, culture and tourism, and leadership capacity to meet Appalachian Regional Commission's strategic investment goals. Gives priority to investments for building a competitive workforce, fostering entrepreneurial activities, developing industry clusters, and broadband initiatives.