Provides an overview of a ten-year U.S. Department of Health and Human Services (HHS) initiative, starting in fiscal year (FY) 2020, to end the epidemic of HIV, which remains a significant public health issue in America. Outlines the Centers for Disease Control and Prevention's (CDC) role in the initiative, working with national, state, and local partners in efforts to diagnose, treat, and prevent new HIV infections, and respond to potential HIV outbreaks. Aims to jump start progress on reducing HIV and prevent a resurgence of the disease across the country. Includes national HIV data snapshots and links to other federal resources on a range of HIV-related topics.

Offers evidence-based opioid overdose prevention practices for community leaders, local and regional organizers, nonprofit groups, law enforcement, public health and other members of the public. Provides summaries of effective strategies to prevent opioid overdose and the context in which they are most effective. Discusses targeted naloxone distribution, including Good Samaritan laws, syringe services programs, criminal justice settings, and medication-assisted treatment (MAT) and initiating MAT in emergency departments. Summarizes the major research on each practice and offers examples of organizations that have successfully used the strategies to reduce the risk of overdose.

Offers comprehensive information and resources on the use of prescription opioids, managing chronic pain, and opioid use disorder (OUD) for patients and providers, specifically for American Indian and Alaska Native (AI/AN) communities and Indian Health Service (IHS) providers. Includes online tools, technical assistance resources, guides, and training for patients and providers on topics such as opioid crisis data, opioid prevention, proper pain management, opioid prescribing/stewardship, culturally appropriate practices, maternal health, harm reduction, naloxone use, child health and wellness, medication-assisted treatment (MAT), tele-MAT, trauma-informed care, best practices, supportive services, wellness courts, and training opportunities. Resource is an initiative of the IHS Alcohol and Substance Abuse Branch (ASAB).