Offers evidence-based information, recommendations, guides, and tools for U.S. Department of Veterans Affairs (VA) and U.S. Department of Defense (DoD) healthcare providers and patients to assist in the decision making process to improve the treatment and outcomes for patients with substance use disorder (SUD), including opioid use disorder (OUD), methamphetamine use, and co-occurring mental health conditions. Describes best practices to help patients avoid preventable complications, reduce substance use, and improve their overall health and wellness.